Volume 10, Issue 2, October 2014, Pages 421–424
Muhammad Kamran Taj1, Zohra Samreen2, Taj Muhammad Hassani3, Imran Taj4, and Wei Yunlin5
1 Kunming University of Science and Technology, Yunnan, China
2 Bolan Medical Hospital Quetta, Balochistan, Pakistan
3 Food and Agriculture Organization, Balochistan, Pakistan
4 Centre for Advanced Studies in Vaccinology and Biotechnology UoB, Balochistan, Pakistan
5 Kunming University of Science and Technology, Yunnan, China
Original language: English
Copyright © 2014 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
According to the cell density bacteria can regulate their gene expression. Gene regulation is initiated by the release of signaling molecules into the environment which are called autoinducers. When the population density increases, these autoinducers accumulate extracellularly and these can be detected by the bacteria through quorum sensing.
We found that E. coli make use of indole quorum-sensing signals to prevent it from infection by T4 phage. This has been acknowledged for the first time that E. coli utilizes antiphage defense mechanism regulated by quorum sensing. We proposed that through quorum sensing E. coli is protected in conditions where there is increased risk of infection as for example during growth in high cellular density in which there is mixed species environments. In microbial communities, quorum-sensing is a general phenomenon which controls E. coli susceptibility to phage.
Author Keywords: Quorum, Sensing. Lysis, Mechanism, T4 Bacteriophage.
Muhammad Kamran Taj1, Zohra Samreen2, Taj Muhammad Hassani3, Imran Taj4, and Wei Yunlin5
1 Kunming University of Science and Technology, Yunnan, China
2 Bolan Medical Hospital Quetta, Balochistan, Pakistan
3 Food and Agriculture Organization, Balochistan, Pakistan
4 Centre for Advanced Studies in Vaccinology and Biotechnology UoB, Balochistan, Pakistan
5 Kunming University of Science and Technology, Yunnan, China
Original language: English
Copyright © 2014 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
According to the cell density bacteria can regulate their gene expression. Gene regulation is initiated by the release of signaling molecules into the environment which are called autoinducers. When the population density increases, these autoinducers accumulate extracellularly and these can be detected by the bacteria through quorum sensing.
We found that E. coli make use of indole quorum-sensing signals to prevent it from infection by T4 phage. This has been acknowledged for the first time that E. coli utilizes antiphage defense mechanism regulated by quorum sensing. We proposed that through quorum sensing E. coli is protected in conditions where there is increased risk of infection as for example during growth in high cellular density in which there is mixed species environments. In microbial communities, quorum-sensing is a general phenomenon which controls E. coli susceptibility to phage.
Author Keywords: Quorum, Sensing. Lysis, Mechanism, T4 Bacteriophage.
How to Cite this Article
Muhammad Kamran Taj, Zohra Samreen, Taj Muhammad Hassani, Imran Taj, and Wei Yunlin, “QUORUM SENSING EFFECT THE LYSIS MECHANISM OF T4 BACTERIOPHAGE,” International Journal of Innovation and Scientific Research, vol. 10, no. 2, pp. 421–424, October 2014.
