|
Twitter
|
Facebook
|
Google+
|
VKontakte
|
LinkedIn
|
 
 
International Journal of Innovation and Scientific Research
ISSN: 2351-8014
 
 
Saturday 17 November 2018

About IJISR

News

Submission

Downloads

Archives

Custom Search

Contact

Connect with IJISR

   
 
 
 

A Review on Chronic Stress Mediated Tumor Angiogenesis through IL-6 & VEGF


Volume 12, Issue 2, December 2014, Pages 420–435

 A Review on Chronic Stress Mediated Tumor Angiogenesis through IL-6 and VEGF

Md. Taifur Rahaman Shanju, Md. Jalal Uddin, Md. Riaz Murshed Chy, and Mahbub E. Sobhani

Original language: English

Received 15 October 2014

Copyright © 2014 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract


Chronic Stress plays a significant role in the progression of tumor angiogenesis through the secretion of Catecholamines, which take part in increased production of IL-6 & VEGF. Chronic psychological stress induces secretion of catecolamines such as epinephrine (E) & noreepinephrine (NE) from adrenal medulla & sympathetic neurons which activate β-adrenergic receptors on tumor cells, which in turn enhances increased production of IL-6. IL-6 then plays a significant role in VEGF production through STAT3 activation. Il-6 follows a series of signaling cascades including cAMP/PKA & MAPK. NF-kB activation through MEK/ERK is crucial for IL-6 production. Angiogenesis, the formation of new blood vessels from preexisting vasculatures is mediated by VEGF. It also takes part in cell proliferation, cell migration & vasculogenesis, thus leading to tumor angiogenesis. The aim of this study was to know the relationship between chronic stress and tumor angiogenesis and to highlight the therapeutic point where further works may proceed on.

Author Keywords: Angiogenesis, Therapeutic, Catecholamines, Epinephrine, Noreepinephrine, Cell Proliferation, Cell Migration and Vasculogenesis.


How to Cite this Article


Md. Taifur Rahaman Shanju, Md. Jalal Uddin, Md. Riaz Murshed Chy, and Mahbub E. Sobhani, “A Review on Chronic Stress Mediated Tumor Angiogenesis through IL-6 & VEGF,” International Journal of Innovation and Scientific Research, vol. 12, no. 2, pp. 420–435, December 2014.