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International Journal of Innovation and Scientific Research
ISSN: 2351-8014
 
 
Monday 30 March 2020

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Viral etiology in patients hospitalized with Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD): A case control study


Volume 16, Issue 2, July 2015, Pages 268–275

 Viral etiology in patients hospitalized with Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD): A case control study

Ajay Kumar Singh, Amita Jain, Bhawana Jain, Tanushree Dangi, Anil Kr Verma, RamAwadh Singh Kushwaha, Surya Kant, Rajiv Garg, and Rajendra Prasad

Original language: English

Received 13 April 2015

Copyright © 2015 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract


Chronic obstructive pulmonary disease is the leading cause of fatality. The course of COPD is followed by episodes of acute deterioration in respiratory health, referred as 'exacerbations'. Acute exacerbations of COPD contribute substantially to the morbidity and mortality due to number of infectious agents including bacteria, viruses, or both. Therefore, we planned a case control study to know the association of respiratory viruses especially HRSV genotype with acute exacerbation of COPD, if any.
This is a prospective case-control study with two groups of patients (AECOPD and stable COPD). Nasopharyngeal aspirate were tested for the detection of Human Respiratory Syncytial Virus; Influenza Viruses; Human Metapneumovirus; Adeno Virus; Human Boca Virus and Parainfluenza Virus 1,2,3,4 by real time PCR.
Respiratory viruses are more often found in case group (AECOPD patients) 45/ 234 patients (19.23%) than in control group (stable COPD), 8/100 patients (8%; P=0.0330). In case group HRSV was detected in 7.6% (18/234) and was most commonly detected virus followed by INFV-A (11/234; 4.7%), INFV-B (10/234; 4.2%), HMPV (2/234; 0.8%), and ADV (4/234; 1.7%). In control group INFV-A was most commonly detected (4/100, 4%), followed by ADV (2/100, 2%) and HRSV (1/100, 1%). No patient tested positive for more than one virus.
Among respiratory viruses, HRSV-A is the most prominent group associated with AECOPD patients. Present study concluded that respiratory viruses play an important role in exacerbation.


Author Keywords: COPD, AECOPD, Viral etiology, Real-time PCR, Respiratory Viruses and HRSV.


How to Cite this Article


Ajay Kumar Singh, Amita Jain, Bhawana Jain, Tanushree Dangi, Anil Kr Verma, RamAwadh Singh Kushwaha, Surya Kant, Rajiv Garg, and Rajendra Prasad, “Viral etiology in patients hospitalized with Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD): A case control study,” International Journal of Innovation and Scientific Research, vol. 16, no. 2, pp. 268–275, July 2015.