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International Journal of Innovation and Scientific Research
ISSN: 2351-8014
 
 
Thursday 22 August 2019

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Trastuzumab in early breast cancer: Literature Review


[ LE TRASTUZUMAB (HERCEPTIN*) dans le traitement du cancer du sein: Revue de la littérature ]

Volume 18, Issue 1, September 2015, Pages 95–98

 Trastuzumab in early breast cancer: Literature Review

Youssef Benabdejlil, Khalid Guelzim, Ihssane Hakimi, Jaouad Kouach, Driss Moussaoui, and Mohammed Dehayni

Original language: French

Received 16 May 2015

Copyright © 2015 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract


Trastuzumab is the first target molecule designed for breast cancer treatment. In first-line metastatic, trastuzumab in combination with chemotherapy significantly improved survival of patients bearing HER2-positive breast cancer. In adjuvant trastuzumab was tested in several randomized trials. In contemporary literature, many strong arguments confirm the clear survival benefit of trastuzumab in adjuvant administered concomitantly with taxane-based chemotherapy and concomitant with radiation therapy, and for a period of one year.

Author Keywords: breast, cancer, trastuzumab, HER, chemotherapy.


Abstract: (french)


Le trastuzumab est la première molécule ciblée conçue pour le traitement du cancer du sein. En première ligne métastatique, le trastuzumab en association avec la chimiothérapie a amélioré significativement la survie des patientes porteuses d'un cancer du sein HER2-positif. En adjuvant, le trastuzumab a été testé dans plusieurs essais randomisés. Dans la littérature médicale contemporaine, plusieurs arguments forts confirment le bénéfice clair en survie du trastuzumab en adjuvant, administré en concomitant avec une chimiothérapie à base de taxanes et en concomitant avec la radiothérapie, et pendant une durée d'une année.

Author Keywords: cancer, sein, trastuzumab, HER, chimiothérapie.


How to Cite this Article


Youssef Benabdejlil, Khalid Guelzim, Ihssane Hakimi, Jaouad Kouach, Driss Moussaoui, and Mohammed Dehayni, “Trastuzumab in early breast cancer: Literature Review,” International Journal of Innovation and Scientific Research, vol. 18, no. 1, pp. 95–98, September 2015.