|
Twitter
|
Facebook
|
Google+
|
VKontakte
|
LinkedIn
|
 
 
International Journal of Innovation and Scientific Research
ISSN: 2351-8014
 
 
Wednesday 23 September 2020

About IJISR

News

Submission

Downloads

Archives

Custom Search

Contact

Connect with IJISR

   
 
 
 

Comparative cytotoxicity of Enantia polycarpa (DC) Engl. and Diels (Annonaceae) and Bersama abissynica Fresen. (Melianthaceae) two Ivorian medicinal species commonly used


Volume 21, Issue 1, March 2016, Pages 183–189

 Comparative cytotoxicity of Enantia polycarpa (DC) Engl. and Diels (Annonaceae) and Bersama abissynica Fresen. (Melianthaceae) two Ivorian medicinal species commonly used

Alain S.A. AMBÉ, BENE Kouadio, Djeneb CAMARA, GNAHOUE Goueh, OUATTARA Djakalia, ZIRIHI Guédé Noel, and Kouakou E. N'GUESSAN

Original language: English

Received 5 December 2015

Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract


In Ivory Coast, the barks of Enantia polycarpa and the leaves of Bersama abissynica, two medicinal species are usually used by populations to treat various diseases such as malaria, diarrheas and cutaneous diseases. To estimate the biological dangers connected to the frequent use of these medicinal plants, the current study was undertaken with objective to evaluate the cytotoxic activity of 70% ethanolic extract on Human Foreskin Fibroblast (HFF) cells in the in vitro culture. 70% ethanolic extract of plants were prepared and the colorimetric test of the MTT is used to evaluate the toxicity of these extracts. The results proved that the ethanolic extract of Enantia polycarpa showed the biggest yield (56,4%). The 70 % éthanlic extract of Bersama abissynica is not cytotoxic at 1000 µg / ml concentration, but mitogen. Our study has shown that the ethanolic extract of Bersama abissynica stimulates HFF cells in division growth (268%). While Enantia polycarpa seems cytotoxic on HFF cells at 1000 µg / ml concentration (36% of viability confluents cells and 55% of viability cells in division). Such results well support that the moderate use of these medicinal plants only represents a limited risk in terms of toxicity. However, follow-up studies must be envisaged in order to determine the chemical compounds responsible of the cytotoxic effect at Enantia polycarpa and those responsible for the mitogen effect at Bersama abissynica.

Author Keywords: toxicity, HFF cells, Enantia polycarpa, Bersama abissynica, Ivory Coast.


How to Cite this Article


Alain S.A. AMBÉ, BENE Kouadio, Djeneb CAMARA, GNAHOUE Goueh, OUATTARA Djakalia, ZIRIHI Guédé Noel, and Kouakou E. N'GUESSAN, “Comparative cytotoxicity of Enantia polycarpa (DC) Engl. and Diels (Annonaceae) and Bersama abissynica Fresen. (Melianthaceae) two Ivorian medicinal species commonly used,” International Journal of Innovation and Scientific Research, vol. 21, no. 1, pp. 183–189, March 2016.