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International Journal of Innovation and Scientific Research
ISSN: 2351-8014
 
 
Thursday 15 November 2018

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Elevation of the transaminases and factors associated at people living with the HIV - AIDS (PVVIH) in the center of Ambulatory Treatment of the PHARMAKINA - BUKAVU (CTA)


[ Elévation des transaminases et facteurs associés chez les personnes vivant avec le VIH -SIDA (PVVIH) au Centre de Traitement Ambulatoire de la PHARMAKINA - BUKAVU (CTA) ]

Volume 26, Issue 1, August 2016, Pages 341–346

 Elevation of the transaminases and factors associated at people living with the HIV - AIDS (PVVIH) in the center of Ambulatory Treatment of the PHARMAKINA - BUKAVU (CTA)

Bonhomme Kalimira Kachelewa, P.P. Lunjwire Mulemangabo, and C. Kyambikwa Bisangamo

Original language: French

Received 9 July 2016

Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract


Objective: To determine the prevalence of the elevation of the hepatic enzymes and factors associated at people living with the VIH - AIDS followed to the CTA PHARMAKINA BUKAVU. Methods: A retrospective transverse study has been led on 171 files of PVVIH having frequented the CTA of the Pharmakina Bukavu during the active period of 2006 to 2013. The data in relation with the biologic state of the PVVIH and the factors of risk of the elevation of the transaminases have been collected and have been analyzed by means of software Ear Info version 3.5.1. The test of Chi-Square and the Odds ratio have been used and the doorstep of significance has been fixed to a p value <0.05. Results: Prevalence of the elevation of the GOT transaminases and GPT were respectively of 66.7% and 47.4%. The GOT transaminases and GPT were raised at the aged PVVIH, of feminine sex, co infected by the viruses of B hepatitis and C, under ARV consuming the alcohol and tobacco. Conclusion: The prevalence of the GOT transaminases and GPT being raised at the PVVIH investigated, a good hold in charge, the non-consumption of alcohol, of tobacco and a regular control of the biologic parameters as the dosages of the hepatic enzymes, the serodiagnosis of hepatitis B and C could reduce the effects hepatotoxicity by our PVVIH.

Author Keywords: transaminases - factors partners, PVVIH, CTA Pharmakina, Bukavu.


Abstract: (french)


Objectif: Déterminer la prévalence de l’élévation des enzymes hépatiques et facteurs associés chez les personnes vivant avec le VIH–SIDA suivies au CTA PHARMAKINA BUKAVU. Matériels et méthodes: Une étude transversale rétrospective a été menée sur 171 dossiers de PVVIH ayant fréquentées le CTA de la Pharmakina Bukavu pendant la période allant de 2006 à 2013. Les données en rapport avec l’état biologique des PVVIH et les facteurs de risque de l’élévation des transaminases ont été collectées et analysées au moyen de logiciel Epi Info version 3.5.1. Le test de Chi-carré et l’Odds ratio ont été utilisés et le seuil de signification a été fixé à une valeur p < 0,05. Résultats: Les prévalences de l’élévation des transaminases GOT et GPT étaient respectivement de 66,7% et 47,4%. Les transaminases GOT et GPT étaient élevées chez les PVVIH âgées, de sexe féminin, co-infectées par les virus des hépatites B et C, sous ARV consommant l’alcool et le tabac. Conclusion: Les prévalences des transaminases GOT et GPT étant élevées chez les PVVIH enquêtées, une bonne prise en charge, la non-consommation d’alcool, du tabac et un contrôle régulier des paramètres biologiques tels que les dosages des enzymes hépatiques, le sérodiagnostic des hépatites B et C pourraient réduire les effets hépatotoxiques auprès de nos PVVIH.

Author Keywords: transaminases- facteurs associés, PVVIH, CTA Pharmakina, Bukavu.


How to Cite this Article


Bonhomme Kalimira Kachelewa, P.P. Lunjwire Mulemangabo, and C. Kyambikwa Bisangamo, “Elevation of the transaminases and factors associated at people living with the HIV - AIDS (PVVIH) in the center of Ambulatory Treatment of the PHARMAKINA - BUKAVU (CTA),” International Journal of Innovation and Scientific Research, vol. 26, no. 1, pp. 341–346, August 2016.