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International Journal of Innovation and Scientific Research
ISSN: 2351-8014
 
 
Saturday 28 May 2022

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BNP, NT-pro BNP tests : Which one to choose in a hospital setting ?


[ Dosage du BNP, NT-pro BNP : Lequel choisir en milieu hospitalier ? ]

Volume 48, Issue 1, April 2020, Pages 21–24

 BNP, NT-pro BNP tests : Which one to choose in a hospital setting ?

Doss Bennani Dounia1, Mahyaoui Zineb2, Morjan Asmaa3, and Kamal Nabiha4

1 Laboratoire de Biochimie, Hôpital Ibn Rochd, CHU Ibn Rochd, Université Hassan II, Faculté de Médecine et de Pharmacie, Casablanca, Maroc
2 Laboratoire de Biochimie, Hôpital Ibn Rochd, CHU Ibn Rochd, Université Hassan II, Faculté de Médecine et de Pharmacie, Casablanca, Maroc
3 Laboratoire d’Immunologie Clinique et d’Immuno-Allergie (LICIA), Faculté de Médecine et de Pharmacie, Université Hassan II, Casablanca, Morocco
4 Laboratoire d’Immunologie Clinique et d’Immuno-Allergie (LICIA), Faculté de Médecine et de Pharmacie, Université Hassan II, Casablanca, Morocco

Original language: French

Copyright © 2020 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract


The role of the natriuretic peptide assay: brain natriuretic peptide (BNP) and N-terminal pro-BNP natriuretic peptide (NT-proBNP) in the diagnosis and prognosis in patients with heart failure has been approved by the Food and Drug Administration (FDA). This dosage is more and more frequently requested in the hospital environment, particularly in the context of the differential diagnosis of dyspnea in a patient presenting to the emergency department. The difficulty for the biologist is to choose between the dosage of BNP biologically active hormone and the assay of NT-proBNP, non-active peptide. This is a bibliographic study that consists of the analysis of different clinical and bibliographic studies that have compared the dosage of these two cardiac markers. The BNP assay is faster and is characterized by a lower glomerular filtration dependence compared to NT-proBNP and a shorter half-life that allows to rapidly monitor its variations. However, because of its excellent stability, the NT-proBNP makes it possible to avoid the false negatives due to the delay of delivery in the university centers. It is performed by automated technique which allows an easy realization of a large number of tests and it also allows a better detection of the early stages of heart failure.

Author Keywords: markers, BNP, NT-proBNP, biochemical assay, hospital setting, heart failure.


How to Cite this Article


Doss Bennani Dounia, Mahyaoui Zineb, Morjan Asmaa, and Kamal Nabiha, “BNP, NT-pro BNP tests : Which one to choose in a hospital setting ?,” International Journal of Innovation and Scientific Research, vol. 48, no. 1, pp. 21–24, April 2020.