Taeniasis is an important worldwide food borne parasitic disease. A cross sectional study was conducted on 540 bovine species from October 2012 to March 2013 to determine prevalence and associated risk factors of cysticercosis at Adigrat Municipal Abattoir. The overall prevalence of cysticercosis was 5.73% (29). Infection prevalence of cysticercosis was significantly associated with age, body condition and breed of cattle (P < 0.05). Infection rate of cysticercosis with respect to age group showed that higher prevalence was in cattle 5 and above years (8.47%) than below 5 years (2.96%) (χ2= 7.949, p = 0.003) and infection rate with respect to body condition revealed the highest prevalence (13.5%) was in poor followed by medium and good body condition scores 4.6 and 1.66%, respectively (χ2= 23.1, p = 0.000). Related to breed of cattle highest prevalence (6.31%) was in Holstine – Fresian followed by local (5.2%) and barka breeds (4.91%) (χ2= 0.211, p = 0.036). However, no significant variation was observed with related to sex of cattle (p > 0.05). Heart (35.56%) was the most infected organ by large number of cysts followed by tongue (23.3 %), masseter muscle (14.4 %), tricept muscle (10 %), liver (8.8 %) and tight muscle (7.7%), respectively. In conclusion, results obtained from this study confirm that cysticercosis is a health problem in cattle in the study area. Therefore, it is necessary to establish appropriate strategy for prevention and controls.