The study on the efficacy of phytosanitary treatment programs based on neem extract or kaolin was undertaken in the center of Benin. The objective of the work was to identify a treatment program that is more effective than the outreach in the area. To achieve this goal, a Fisher block device with 6 treatments and 4 repetitions were set up on two sites. The treatments developed consisted of an untreated plot; of a treated plot to the program popularized (PP); of a plot treated exclusively in Kaolin 5%; of a plot receiving: 3 neem-2 emamectine/acetamipride-2 neem; of a plot receiving: 2 emamectine/acetamipride -2 neem-1 emamectine/acetamipride -2 neem and of a plot treated in the mixture of neem + emamectine/acetamipride on 7 applications. Ten applications were conducted with the kaolin used alone and 7 with the other objects. The results showed good control of endocarpiques larvae by programs N°4 and N°6, consisting respectively of 3neem-2 emamectine/acetamipride-2 neem and of 7 treatments in the neem mixture emamectine/acetamipride. The average number of larvae in the green bolls obtained on plots treated following these two programs has not been statistically different from that of the treated plots following the program popularized in the area. This average number of larvae was also reduced as compared to untreated parcels (p=0.0029). The program exclusive to the kaolin 5% has controlled the endocarpiques larvae, Pectinophora gossypiella and Thaumatotibia leucotreta as well as the popularized program. The number of plants attacked by pests of foliage, including Haritalodes derogata and Aphis gossypii has been reduced respectively by 34.7% and 47% against 95.6 and 82.4% on average by the other treatment programs. The program N°5, starting by two treatments to emamectine/acetamipride was in contrast less effective on the control of the endocarpiques larvae in the area. This study has shown that phytosanitary treatment program consisting of applications of neem extracts alternating or in mixture with an alternative product to pyrethroids can effectively control endocarpiques larvae on cotton, limiting resistance to insecticides and reduce The stress on environment due to chemicals.