Objective: Given the importance in Guinea of ​​the informal economy with an estimated share of 43% of GDP and 96% of jobs. The profession of welder, like other professions in the informal sector, is not exercised without risk. Our study aimed to assess the occupational risks associated with welding in the workshops of the municipality of Matoto, Conakry. Method: This was a prospective descriptive study lasting one year from January 5, 2021 to December 31, 2021. Welders from the informal professional sector in the welding workshops of the municipality of Matoto, who were present and who agreed to participate in the study, were included. The data were analyzed using the Epi-info statistical software version 7.2.2.6. Result: We registered 212 male welders. The average age of the welders was 28.33 ± 12.46 years. The age group from 15 to 29 years old was the most represented at 59.3%. Common damage was arc flash 88.2%; followed by skin burns 84.4%, hand cuts/wounds 78.3. Only 0.5% of workshops had a fire extinguisher, 3.3% handling accessories. The occurrence of arc flash was significantly associated with exposure to UV/IR from the welding arc (p = 0.0000). Foreign body in the eye was associated with full-time work (p = 0.0024). Conclusion: The welder’s experienced significant eye and skin morbidity accentuated by the non-use of collective and individual protective measures. Factors such as level of education, income, seniority and full-time work were significantly associated with self-reported injuries and PPE use among welders (p ˂ 0.05).